Nano Archive

Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells

Green, Jordan J. and Chiu, Eugene and Leshchiner, Elizaveta S. and Shi, Julie and Langer, Robert and Anderson, Daniel G. (2007) Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells. NANO LETTERS, 7 (4). pp. 874-879. ISSN 1530-6984

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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl062395b

Abstract

A general method of coating polymer/DNA nanoparticles was developed. Peptide coated nanoparticles were found to have favorable biophysical characteristics including small particle size, near-neutral zeta potential, and stability in serum. At appropriate formulation conditions including near-neutral charge ratio, the coated nanoparticles enabled effective ligand-specific gene delivery to human primary endothelial cells in serum-containing media. As this nanoparticulate drug delivery system has high efficacy, ligand-based specificity, biodegradability, and low cytotoxicity, it may be potentially useful in several clinical applications.

Item Type:Article
Subjects:Biomedical Science > Nanomedicine
ID Code:2187
Deposited By:M T V
Deposited On:22 Dec 2008 15:47
Last Modified:22 Dec 2008 15:47

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