Green, Jordan J. and Chiu, Eugene and Leshchiner, Elizaveta S. and Shi, Julie and Langer, Robert and Anderson, Daniel G. (2007) Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells. NANO LETTERS, 7 (4). pp. 874-879. ISSN 1530-6984
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Official URL: http://pubs.acs.org/doi/abs/10.1021/nl062395b
A general method of coating polymer/DNA nanoparticles was developed. Peptide coated nanoparticles were found to have favorable biophysical characteristics including small particle size, near-neutral zeta potential, and stability in serum. At appropriate formulation conditions including near-neutral charge ratio, the coated nanoparticles enabled effective ligand-specific gene delivery to human primary endothelial cells in serum-containing media. As this nanoparticulate drug delivery system has high efficacy, ligand-based specificity, biodegradability, and low cytotoxicity, it may be potentially useful in several clinical applications.
|Subjects:||Biomedical Science > Nanomedicine|
|Deposited By:||M T V|
|Deposited On:||22 Dec 2008 15:47|
|Last Modified:||22 Dec 2008 15:47|
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