Nano Archive

Multifunctionalized polymer microcapsules: Novel tools for biological and pharmacological applications

Sukhorukov, Gleb B. and Rogach, Andrey L. and Garstka, Malgorzata and Springer, Sebastian and Parak, Wolfgang J. and Munoz-Javier, Almudena and Kreft, Oliver and Skirtach, Andre G. and Susha, Andrei S. and Ramaye, Yannic and Palankar, Raghavendra and Winterhalter, Mathias (2007) Multifunctionalized polymer microcapsules: Novel tools for biological and pharmacological applications. SMALL, 3 (6, Sp. Iss. SI). pp. 944-955. ISSN 1613-6810 (print), 1613-6829 (online)

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Official URL: http://www3.interscience.wiley.com/journal/1142508...

Abstract

We describe recent developments with multifunctional nanoengineered polymer capsules. In addition to their obvious use as a delivery system, multifunctional nanocontainers find wide application in enzymatic catalysis, controlled release, and directed drug delivery in medicine. The multifunctionality is provided by the following components: 1) Luminescent semiconductor nanocrystals (quantum dots) that facilitate imaging and identification of different capsules, 2) superparamagnetic nanoparticles that allow manipulation of the capsules in a magnetic field, 3) surface coatings, which target the capsules to desired cells, 4) metallic nanoparticles in the capsule wall that act as an absorbing antenna for electromagnetic fields and provide heat for controlled release, and 5) enzymes and pharmaceutical agents that allow specific reactions. The unique advantage of multifunctional microcapsules in comparison to other systems is that they can be simultaneously loaded/functionalized with the above components, allowing for the combination of their properties in a single object.

Item Type:Article
Uncontrolled Keywords:controlled release; drug delivery; microcapsules; polymers; quantum dots
Subjects:Material Science > Functional and hybrid materials
Biomedical Science > Nanomedicine
ID Code:2172
Deposited By:M T V
Deposited On:02 Jan 2009 10:53
Last Modified:02 Jan 2009 10:53

Repository Staff Only: item control page