Geng, Yan and Dalhaimer, Paul and Cai, Shenshen and Tsai, Richard and Tewari, Manorama and Minko, Tamara and Discher, Dennis E. (2007) Shape effects of filaments versus spherical particles in flow and drug delivery. NATURE NANOTECHNOLOGY, 2 (4). pp. 249-255. ISSN ISSN: 1748-3387; EISSN: 1748-3395
Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.
Official URL: http://www.nature.com/nnano/journal/v2/n4/abs/nnan...
Interaction of spherical particles with cells and within animals has been studied extensively, but the effects of shape have received little attention. Here we use highly stable, polymer micelle assemblies known as filomicelles to compare the transport and trafficking of flexible filaments with spheres of similar chemistry. In rodents, filomicelles persisted in the circulation up to one week after intravenous injection. This is about ten times longer than their spherical counterparts and is more persistent than any known synthetic nanoparticle. Under fluid flow conditions, spheres and short filomicelles are taken up by cells more readily than longer filaments because the latter are extended by the flow. Preliminary results further demonstrate that filomicelles can effectively deliver the anticancer drug paclitaxel and shrink human-derived tumours in mice. Although these findings show that long-circulating vehicles need not be nanospheres, they also lend insight into possible shape effects of natural filamentous viruses.
|Subjects:||Material Science > Nanochemistry|
Biomedical Science > Nanomedicine
|Deposited By:||M T V|
|Deposited On:||02 Jan 2009 13:02|
|Last Modified:||02 Jan 2009 13:02|
Repository Staff Only: item control page