Nano Archive

Synthesis of copolymer submicron microspheres encapsulated by fluorescent semiconductor CdSe/ZnS nanocrystals

Generalova, A. N. and Sizova, S. V. and Goncova, M. S. and Klinov, D. V. and Mochalov, K. E. and Zubov, V. P. and Oleynikov, V. A. and Artem'ev, M. V. and Baranov, Alexander V. and Maslov, V. G. (2007) Synthesis of copolymer submicron microspheres encapsulated by fluorescent semiconductor CdSe/ZnS nanocrystals. Nanotechnologies in Russia, Volume 2 (7-8). pp. 144-154.

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Methods of synthesis, properties and application examples of copolymer (acrolein/styrene) submicron fluorescent microspheres are described. Semiconductors core/shell CdSe/ZnS nanocrystals of CdSe core diameter from 2.2 to 5.0 nm fluorescing in 520–620 nm range depending on the core size are used as fluorophore. Monodispersed polymer microspheres with characteristic 200–500 nm size obtained by precipitation polymerization in water-alkaline medium emulsifier-free radical polymerization of acrolein as well as radical copolymerization of acrolein and styrene. The synthesized microspheres contain aldehyde groups on the surface, which easily react with protein molecules amides. The method of semiconductor ZnS/CdSe nanocrystals encapsulation within polymer particles was developed. It was found that copolymer particles synthesized by emulsifier-free radical copolymerization with monomer ratio acrolein:styrene, 1:1 had the highest fluorescence intensity, uniform nanocrystals distribution, and stable in colloids. The opportunity of fluorescence submicron particles application in immunoassy (for detection of antigen Y. Pestis) and in cytofluorimery (Jurkat cells labeling) were demonstrated.

Item Type:Article
Subjects:Physical Science > Nanoelectronics
ID Code:2148
Deposited By:Prof. Alexey Ivanov
Deposited On:19 Dec 2008 13:13
Last Modified:26 Mar 2009 11:28

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