Nano Archive

Vertically aligned carbon nanotube probes for monitoring blood cholesterol

Roy, Somenath and Vedala, Harindra and Choi, Wonbong (2006) Vertically aligned carbon nanotube probes for monitoring blood cholesterol. Nanotechnology, 17 (4). S14-S18.

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Detection of blood cholesterol is of great clinical significance. The amperometric detection technique was used for the enzymatic assay of total cholesterol. Multiwall carbon nanotubes(MWNTs), vertically aligned on a silicon platform, promote heterogeneous electron transfer between the enzyme and the working electrode. Surface modification of the MWNT with a biocompatible polymer, polyvinyl alcohol(PVA), converted the hydrophobic nanotube surface into a highly hydrophilic one, which facilitates efficient attachment of biomolecules. The fabricated working electrodes showed a linear relationship between cholesterol concentration and the output signal. The efficacy of the multiwall carbon nanotubes in promoting heterogeneous electron transfer was evident by distinct electrochemical peaks and higher signal-to-noise ratio as compared to the Au electrode with identical enzyme immobilization protocol. The selectivity of the cholesterol sensor in the presence of common interferents present in human blood, e.g.uric acid, ascorbic acid and glucose, is also reported.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
ID Code:212
Deposited By:Lesley Tobin
Deposited On:18 Nov 2008 15:33
Last Modified:30 Jan 2009 17:22

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