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Preparation and properties of associates of nickel nanoparticles with ss-DNA and proteins

Pozmogova, G. E. and Chuvilin, A. N. and Smirnov, I. P. and Zaitseva, M. A. (2008) Preparation and properties of associates of nickel nanoparticles with ss-DNA and proteins. Nanotechnologies in Russia, Volume 3 (5-6). pp. 391-396.

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In this paper, we demonstrate that nickel nanoparticles are suitable and promising for forming multifunctional biopolymer structures and have advantages over other nanoplatforms. We found that aggregates of nickel nanoparticles form stable associates with fragments of single-stranded DNA (ss-DNA). The impact of the oligomer length, nucleotide composition, nature of the internucleotide bond, and association conditions on the structure and properties of the complexes was studied. The protein-nickel associates were studied for two recombinant histidine-tagged proteins, for which the isotherms of adsorption were obtained. Biopolymer molecules incorporated in associates do not degrade and can retain (completely or partially) their functionality. Therefore, they can be used for selection of aptamers with binding affinity for proteins. The results contribute to the development of new biopolymer-nickel nanostructures, which have potential as research and diagnostic tools in the fields of molecular nanoelectronics, biology, and medicine.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
ID Code:2079
Deposited By:Prof. Alexey Ivanov
Deposited On:19 Dec 2008 13:15
Last Modified:01 Feb 2009 20:41

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