Nano Archive

Porphyrin-fullerene nanoparticles for treatment of hypoxic cardiopathies

Amirshahi, N and Alyautdin, R. N. and Sarkar, S and Rezayat, S. M. and Orlova, M. A. and Trushkov, I. V. and Buchachenko, A. L. and Kuznetsov , D. A. (2008) Porphyrin-fullerene nanoparticles for treatment of hypoxic cardiopathies. Nanotechnologies in Russia, Volume 3 (9-10). pp. 611-621.

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Official URL: http://www.springerlink.com/content/747563752k1372...

Abstract

In this study, low-toxic fullerene-based nanocationite particles (adducts of porphyrin with cyclohexyl fullerene C60) designated for targeted delivery of the paramagnetic stable magnesium isotope to heart muscle is reported for the first time; these particles exhibit a sharp clinical effect of 80% recovery from tissue hypoxia in less than 24 h after a single injection (0.03–0.1 LD50). This therapy is based on a novel principle: 25Mg2+ released by nanoparticles due to the magnetic isotopic effect selectively stimulates the additional production of ATP in oxygen-depleted cells. These cationite “smart nanoparticles,” which possess a membranotropic effect, release hyperactivating paramagnetic cations only in response to a metabolic acidic shift. The final positive changes in the energy metabolism of heart muscle cells are capable of helping to prevent and/or treat local hypoxia of heart muscle, and therefore, protect heart muscle from serious damage in a wide variety of clinical cases of hypoxia, including cardiotoxic side effects of doxorubicin and 1-methylnicotineamide. Both the pharmacokinetics and pharmacodynamics of the proposed drug allow safe and efficient administration in single-and multi-injection (acute and chronic) therapeutic schemes.

Item Type:Article
Subjects:Biomedical Science > Nanotechnology for human health
ID Code:2055
Deposited By:Prof. Alexey Ivanov
Deposited On:19 Dec 2008 13:10
Last Modified:12 Feb 2009 12:42

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