Chang, Yi-Ren and Lee, Hsu-Yang and Chen, Kowa and Chang, Chun-Chieh and Tsai, Dung-Sheng and Fu, Chi-Cheng and Lim, Tsong-Shin and Tzeng, Yan-Kai and Fang, Chia-Yi and Han, Chau-Chung and Chang, Huan-Cheng and Fann, Wunshain (2008) Mass production and dynamic imaging of fluorescent nanodiamonds. NATURE NANOTECHNOLOGY, 3 (5). pp. 284-288.
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Official URL: http://www.nature.com/nnano/journal/v3/n5/abs/nnan...
Fluorescent nanodiamond is a new nanomaterial that possesses several useful properties, including good biocompatibility(1), excellent photostability(1,2) and facile surface functionalizability(2,3). Moreover, when excited by a laser, defect centres within the nanodiamond emit photons that are capable of penetrating tissue, making them well suited for biological imaging applications(1,2,4). Here, we show that bright fluorescent nanodiamonds can be produced in large quantities by irradiating synthetic diamond nanocrystallites with helium ions. The fluorescence is sufficiently bright and stable to allow three-dimensional tracking of a single particle within the cell by means of either one- or two-photon-excited fluorescence microscopy. The excellent photophysical characteristics are maintained for particles as small as 25 nm, suggesting that fluorescent nanodiamond is an ideal probe for long-term tracking and imaging in vivo, with good temporal and spatial resolution.
|Subjects:||Material Science > Functional and hybrid materials|
Material Science > Nanofabrication processes and tools
Technology > Manufacturing processes for nanotechnology
|Deposited By:||Farnush Anwar|
|Deposited On:||23 Dec 2008 12:07|
|Last Modified:||09 Jan 2009 16:11|
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