Nano Archive

Simulation of the electric response of DNA translocation through a semiconductor nanopore–capacitor

Gracheva, Maria E. and Xiong, Anlin and Aksimentiev, Aleksei and Schulten, Klaus and Timp, Gregory and Leburton, Jean-Pierre (2006) Simulation of the electric response of DNA translocation through a semiconductor nanopore–capacitor. Nanotechnology, 17 (3). pp. 622-633. ISSN 09574484

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Official URL: http://dx.doi.org/10.1088/0957-4484/17/3/002

Abstract

A multi-scale/multi-material computational model for simulation of the electric signal detected on the electrodes of a metal–oxide–semiconductor (MOS) capacitor forming a nanoscale artificial membrane, and containing a nanopore with translocating DNA, is presented. The multi-scale approach is based on the incorporation of a molecular dynamics description of a translocating DNA molecule in the nanopore within a three-dimensional Poisson equation self-consistent scheme involving electrolytic and semiconductor charges for the electrostatic potential calculation. The voltage signal obtained from the simulation supports the possibility for single nucleotide resolution with a nanopore device. The electric signal predicted on the capacitor electrodes complements ongoing experiments exploring the use of nanopores in a MOS capacitor membrane for DNA sequencing.

Item Type:Article
Subjects:Biomedical Science > Nanobiotechnology
Physical Science > Nanoelectronics
ID Code:182
Deposited By:Lesley Tobin
Deposited On:13 Nov 2008 11:43
Last Modified:26 Mar 2009 14:53

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