Wick, Peter and Manser, Pius and Limbach, Ludwig K. and Dettlaff-Weglikowska, Ursula and Krumeich, Frank and Roth, Siegmar and Stark, Wendelin J. and Bruinink, Arie (2007) The degree and kind of agglomeration affect carbon nanotube cytotoxicity. TOXICOLOGY LETTERS, 168 (2). pp. 121-131.
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The urgent need for toxicological studies on carbon nanotubes (CNTs) has arisen from the rapidly emerging applications of CNTs well beyond material science and engineering. In order to provide a basis for comparison to existing epidemiological data, we have investigated CNTs at various degrees of agglomeration using an in vitro cytotoxicity study with human MSTO-211H cells. Non-cytotoxic polyoxyethylene sorbitan monooleate was found to well-disperse CNT. In the present study, the cytotoxic effects of well-dispersed CNT were compared with that of conventionally purified rope-like agglomerated CNTs and asbestos as a reference. While suspended CNT-bundles were less cytotoxic than asbestos, rope-like agglomerates induced more pronounced cytotoxic effects than asbestos fibres at the same concentrations. The study underlines the need for thorough materials characterization prior to toxicological studies and corroborates the role of agglomeration in the cytotoxic effect of nanomaterials. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
|Uncontrolled Keywords:||single wall carbon nanotubes; toxicity; in vitro tests; suspension nanoparticle risk; polyoxyethylene sorbitan monooleate|
|Subjects:||NanoSafety > Environment, health and safety aspects of nanotechnology|
|Deposited By:||Mark Morrison|
|Deposited On:||08 Jan 2009 12:08|
|Last Modified:||08 Jan 2009 12:08|
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