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Biofunctional subwavelength optical waveguides for biodetection

Sirbuly, Donald J. and Fischer, Nicholas O. and Huang, Shih-Chieh J. and Artyukhin, Alexander B. and Tok, Jeffrey B. -H. and Bakajin, Olgica and Noy, Aleksandr (2008) Biofunctional subwavelength optical waveguides for biodetection. ACS NANO, 2 (2). pp. 255-262.

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We report a versatile biofunctional subwavelength photonic device platform for real-time detection of biological molecules. Our devices contain lipid bilayer membranes fused onto metal oxide nanowire waveguides stretched across polymeric flow channels. The lipid bilayers incorporating target receptors are submersed in the propagating evanescent field of the optical cavity. We show that the lipid bilayers in our devices are continuous, have very high mobile fraction, and are resistant to fouling. We also demonstrate that our platform allows rapid membrane exchange. Finally, we use this device to detect the hybridization of specific DNA target sequences in solution to complementary probe DNA strands anchored to the lipid bilayer. This evanescent wave sensing architecture holds great potential for portable, all-optical detection systems.

Item Type:Article
Uncontrolled Keywords:photonics; evanescent field; subwavelength; sensor; lipid bilayer; waveguide
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Physical Science > Photonics
ID Code:1495
Deposited By:Farnush Anwar
Deposited On:11 Dec 2008 20:05
Last Modified:11 Dec 2008 20:05

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