Nano Archive

A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response

Zhou, Hongyu and Mu, Qingxin and Gao, Ningning and Liu, Aifeng and Xing, Yuehan and Gao, Sulian and Zhang, Qiu and Qu, Guangbo and Chen, Yuyan and Liu, Gang and Zhang, Bin and Yan, Bing (2008) A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response. NANO LETTERS, 8 (3). pp. 859-865.

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Official URL: http://dx.doi.org/10.1021/nl0730155

Abstract

We have discovered functionalized multiwalled carbon nanotubes with reduced protein-binding, cytotoxicity, and immune response and the associated structure-activity relationships using in silico surface molecular diversity design, combinatorial library synthesis, and multiple biological screenings. Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research.

Item Type:Article
Subjects:Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:1390
Deposited By:Anuj Seth
Deposited On:09 Dec 2008 10:55
Last Modified:20 Jan 2009 09:40

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