Nano Archive

Antifungal effect of silver nanoparticles on dermatophytes.

Kim, Keuk-Jun and Sung, Woo Sang and Moon, Seok-Ki and Choi, Jong-Soo and Kim, Jong Guk and Lee, Dong Gun (2008) Antifungal effect of silver nanoparticles on dermatophytes. Journal of microbiology and biotechnology, 18 (8). pp. 1482-4. ISSN 1017-7825

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/18756112

Abstract

Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 mug/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 mug/ml; fluconazole IC80, 10- 30 mug/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications.

Item Type:Article
Uncontrolled Keywords:Silver nanoparticles, antifungal effect, Trichophyton mentagrophytes, Candida species
Subjects:Biomedical Science > Nanotechnology for human health
ID Code:13
Deposited By:Lesley Tobin
Deposited On:10 Oct 2008 15:19
Last Modified:22 Jan 2009 13:35

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