Rajkumar, Rajagopal and Katterle, Martin and Warsinke, Axel and Moehwald, Helmuth and Scheller, Frieder W. (2008) Thermometric MIP sensor for fructosyl valine. BIOSENSORS & BIOELECTRONICS, 23 (7). pp. 1195-1199.
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Official URL: http://dx.doi.org/10.1016/j.bios.2007.09.015
Interactions of molecularly imprinted polymers containing phenyl boronic acid residues with fructosyl valine, fructose and pinacol, respectively are analysed in aqueous solution (pH 11.4) by using a flow calorimeter. The reversible formation of (two) cyclic boronic acid diesters per fructosyl molecule generates a 40-fold higher exothermic signal as compared to the control polymer. Whereas binding of pinacol to either the MIP or the control polymer generates a very small endothermic signal reflecting a negligible contribution of the esterification to the overall process. An ``apparent imprinting factor'' of 41 is found which exceeds the respective value of batch binding procedures by a factor of 30. Furthermore, the MIP sensor was used to characterise the crossreactivity. The influence of shape selective molecular recognition is discussed. (c) 2007 Elsevier B.V. All rights reserved.
|Subjects:||Physical Science > Nanophysics|
Material Science > Nanochemistry
|Deposited By:||Anuj Seth|
|Deposited On:||15 Dec 2008 13:22|
|Last Modified:||11 Aug 2009 07:22|
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