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Thermometric MIP sensor for fructosyl valine

Rajkumar, Rajagopal and Katterle, Martin and Warsinke, Axel and Moehwald, Helmuth and Scheller, Frieder W. (2008) Thermometric MIP sensor for fructosyl valine. BIOSENSORS & BIOELECTRONICS, 23 (7). pp. 1195-1199.

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Official URL: http://dx.doi.org/10.1016/j.bios.2007.09.015

Abstract

Interactions of molecularly imprinted polymers containing phenyl boronic acid residues with fructosyl valine, fructose and pinacol, respectively are analysed in aqueous solution (pH 11.4) by using a flow calorimeter. The reversible formation of (two) cyclic boronic acid diesters per fructosyl molecule generates a 40-fold higher exothermic signal as compared to the control polymer. Whereas binding of pinacol to either the MIP or the control polymer generates a very small endothermic signal reflecting a negligible contribution of the esterification to the overall process. An ``apparent imprinting factor'' of 41 is found which exceeds the respective value of batch binding procedures by a factor of 30. Furthermore, the MIP sensor was used to characterise the crossreactivity. The influence of shape selective molecular recognition is discussed. (c) 2007 Elsevier B.V. All rights reserved.

Item Type:Article
Subjects:Physical Science > Nanophysics
Material Science > Nanochemistry
ID Code:1283
Deposited By:Anuj Seth
Deposited On:15 Dec 2008 13:22
Last Modified:11 Aug 2009 07:22

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