Nano Archive

Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten

Sun, Nijuan and McMullan, Martin and Papakonstantinou, Pagona and Gao, Hui and Zhang, Xinxiang and Mihailovic, Dragan and Li, Meixian (2008) Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten. ANALYTICAL CHEMISTRY, 80 (10). pp. 3593-3597.

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Official URL: http://dx.doi.org/10.1021/ac7024893

Abstract

We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
ID Code:1236
Deposited By:Anuj Seth
Deposited On:16 Dec 2008 09:55
Last Modified:19 Jan 2009 11:22

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