Sun, Nijuan and McMullan, Martin and Papakonstantinou, Pagona and Gao, Hui and Zhang, Xinxiang and Mihailovic, Dragan and Li, Meixian (2008) Bioassembled nanocircuits of Mo6S9-xIx nanowires for electrochemical immunodetection of estrone hapten. ANALYTICAL CHEMISTRY, 80 (10). pp. 3593-3597.
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Official URL: http://dx.doi.org/10.1021/ac7024893
We demonstrate a novel and highly sensitive electrochemical detection of estrone based on an immunosensor platform, composed of bioassembled nanocircuits of Mo6S9-xIx nanowires (MoSI NWs) covalently connected to anti-estrone antibodies. The one-step, label-free, and quantitative detection of estrone is realized by employing the [Ru(NH3)(6)](3+/2+) redox ions to sense anti-estrone antibody and estrone interactions. The MoSI NWs/anti-estrone antibody nanocircuit architectures provide an amplification and conductive pathway for the specific electrochemical sensing of estrone hapten. A detection limit of 1.4 pg.mL(-1) was achieved in contrast to previous electrochemical techniques in which the sensitivity was limited to the nanomolar range.
|Subjects:||Analytical Science > Nanotechnology for sensing and actuating|
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
|Deposited By:||Anuj Seth|
|Deposited On:||16 Dec 2008 09:55|
|Last Modified:||19 Jan 2009 11:22|
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