Nano Archive

Nanomonitors: Protein biosensors for rapid analyte analysis

Reddy, Ravikiran K. and Bothara, Manish G. and Barrett, Thomas W. and Carruthers, John and Prasad, Shalini (2008) Nanomonitors: Protein biosensors for rapid analyte analysis. IEEE SENSORS JOURNAL, 8 (5-6). pp. 720-723.

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Official URL: http://ieeexplore.ieee.org/Xplore/login.jsp?url=/s...

Abstract

A technology for electrical detection of proteins has been developed using electrical conductance measurements. It is based on developing high density, low-volume multiwell plate devices. The scientific core of this technology lies in integrating nanoporous membranes with. microfabricated chip platforms. This results in the conversion of individual pores into wells of picoliter volume. Specific antibodies are localized and isolated into individual wells. The formation of the antibody-antigen binding complex occurs in individual wells. The membrane allows for robust separation among individual wells. This technology has the capability to achieve near real-time detection with improved sensitivity and selectivity.

Item Type:Article
Uncontrolled Keywords:cardiac markers; clinical diagnostics; conductance measurements; electrical protein sensor
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanobiotechnology
Material Science > Nanochemistry
Material Science > Nanostructured materials
ID Code:1209
Deposited By:Anuj Seth
Deposited On:16 Dec 2008 13:52
Last Modified:18 Feb 2009 17:55

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