Nano Archive

Universal bio-molecular signal transduction-based nano-electronic bio-detection system

Maki, Wusi C. and Mishra, Nirankar N. and Rastogi, Shiva K. and Cameron, Eric G. and Filanoski, Brian and Winterrowd, Paul and Maki, Gary K. (2008) Universal bio-molecular signal transduction-based nano-electronic bio-detection system. SENSORS AND ACTUATORS B-CHEMICAL, 133 (2). pp. 547-554.

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The development of rapid and ultra-sensitive detection technologies is a long-standing goal for researchers in the bio-detection fields. Nanowire field-effect transistor (nano-FET) devices have shown great promise in label-free and ultra sensitive detection of biological agents. However, critical application problems ill using this technology have not been addressed, particularly the difficulties of FET sensing surface modification for various targets and lower detection specificity in real biological samples. A novel molecular signal transduction system reported herein overcomes such problems. With this system, various complicated bio-molecular interactions are ``translated'' into simple signal molecules with universal sequences. These signal molecules are captured on the sensing surface of nano-FET devices through sequence-specific recognition and generate detectable electronic signals. Using this system, nano-FET devices become universal for detecting almost any bio-agents. Staphylococcus aureus was used as the target to demonstrate the detection of DNA, RNA and protein on the same nano-FET device. Detection sensitivity was achieved at 25 fM levels in pure sample. (C) 2008 Elsevier B.V. All rights reserved.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanobiotechnology
Material Science > Nanostructured materials
ID Code:1199
Deposited By:Anuj Seth
Deposited On:16 Dec 2008 14:20
Last Modified:18 Feb 2009 17:43

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