Ramachandran, Lakshmy and Nair, Cherupally Krishnan Krishnan (2011) Therapeutic Potentials of Silver Nanoparticle Complex of alpha-Lipoic Acid. Nanomaterials and Nanotechnology, 1 (2). pp. 17-24. ISSN 1847-9804
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Official URL: http://www.intechopen.com/journals/show/nanomateri...
Abstract
Silver (SN) nanoparticles were re-dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha- Lipoic acid (LA). The nanoparticle - LA complex (SN-LA) was characterized using SEM. SN- LA exhibited DPPH radical scavenging activity in vitro and anti- inflammatory activity against acute and chronic paw models of edema in mice. SN-LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN-LA administration to tumour- bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN-LA as a therapeutic adjuvant during cancer radiotherapy.
| Item Type: | Article |
|---|---|
| Subjects: | Material Science > Nanochemistry Material Science > Nanostructured materials Biomedical Science > Nanomedicine |
| ID Code: | 11899 |
| Deposited By: | Miss Sara Uhac |
| Deposited On: | 14 Aug 2012 10:33 |
| Last Modified: | 14 Aug 2012 10:33 |
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