Nano Archive

Therapeutic Potentials of Silver Nanoparticle Complex of alpha-Lipoic Acid

Ramachandran, Lakshmy and Nair, Cherupally Krishnan Krishnan (2011) Therapeutic Potentials of Silver Nanoparticle Complex of alpha-Lipoic Acid. Nanomaterials and Nanotechnology, 1 (2). pp. 17-24. ISSN 1847-9804

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Silver (SN) nanoparticles were re-dispersed in aqueous solution of Pluronic F127 and complexed with the antioxidant, alpha- Lipoic acid (LA). The nanoparticle - LA complex (SN-€LA) was characterized using SEM. SN-€ LA exhibited DPPH radical scavenging activity in vitro and anti- inflammatory activity against acute and chronic paw models of edema in mice. SN-€LA protected mice from whole body gamma radiation induced body weight losses and mortality revealing its radioprotecting capacity. Meanwhile, SN-LA administration to tumour-€ bearing mice prior to whole body gamma radiation exposure, aided in better tumour growth delay. The results suggest the feasibility in using SN-LA as a therapeutic adjuvant during cancer radiotherapy.

Item Type:Article
Subjects:Material Science > Nanochemistry
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
ID Code:11899
Deposited By:Mr Sasa Marcan
Deposited On:14 Aug 2012 10:33
Last Modified:14 Aug 2012 10:33

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