Prow, Tarl W and Monteiro-Riviere, Nancy A and Inman, Alfred O and Grice, Jeffrey E and Chen, Xianfeng and Zhao, Xin and Sanchez, Washington H and Gierden, Audrey and Kendall, Mark A and Zvyagin, Andrei V and Erdmann, Detlev and Riviere, Jim E and Roberts, Michael S. (2012) Quantum dot penetration into viable human skin. Nanotoxicology .
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Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine. In this study, we use laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped. Quantum dot (QD) fluorescent nanoparticles with three surface modifications: Polyethylene glycol (PEG), PEG-amine (PEG-NH2) and PEG-carboxyl (PEG-COOH) were evaluated for human skin penetration from aqueous solutions at pH 7.0 and at pHs of solutions provided by the QD manufacturer: 8.3 (PEG, PEG-NH2) and 9.0 (PEG-COOH). There was some penetration into intact viable epidermis of skin for the PEG-QD at pH 8.3, but not at pH 7.0 nor for any other QD at the pHs used. Upon tape stripping 30 strips of stratum corneum, all QDs penetrated through the viable epidermis and into the upper dermis within 24 h.
|Subjects:||Risk > Environment, health and safety aspects of nanotechnology|
|Deposited By:||Prof Nancy Monteiro-Riviere|
|Deposited On:||02 Mar 2012 20:26|
|Last Modified:||02 Mar 2012 20:26|
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