Nano Archive

Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods

Samberg, Meghan E and Orndorff, Paul E and Monteiro-Riviere, Nancy A (2011) Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods. Nanotoxicology .

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Abstract

Silver nanoparticles (Ag-nps) are used as a natural biocide to prevent undesired bacterial growth in clothing and cosmetics. The objective of this study was to assess the antibacterial efficacy of Ag-nps of different sizes, surface conditions, and synthesis methods against Escherichia coli, Ag-resistant E. coli, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and Salmonella sp. Ag-nps samples were synthesized by: Base reduction with unmodified surfaces and used as synthesized (‘unwashed’; 20, 50 and 80 nm) or after 20 phosphate buffer washes (‘washed’; 20, 50 and 80 nm), or synthesized by laser ablation with carbon-stabilized surfaces (‘carbon-coated’; 25 and 35 nm). Unwashed Ag-nps were toxic to all bacterial strains at concentrations between 3.0–8.0 mg/ml. The washed Ag-nps and carbon-coated Ag-nps were toxic to all bacterial strains except Ag-resistant E. coli at concentrations between 64.0–1024.0 mg/ml. Ag-resistant E. coli died only when treated with unwashed Ag-nps or its supernatant, both of which contained formaldehyde.

Item Type:Article
Subjects:NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:11798
Deposited By:Prof Nancy Monteiro-Riviere
Deposited On:02 Mar 2012 19:46
Last Modified:02 Mar 2012 19:46

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