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Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model

Lee, Hyun A and Leavens, Teresa L and Mason, Sharon E and Monteiro-Riviere, Nancy A and Riviere, Jim E (2009) Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model. Nano Letters .

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Abstract

A physiologically based pharmacokinetic model with partition coefficients estimated from quantum dot (QD) 705 biodistribution was compared with the biodistribution of other QDs in mice and rats to determine the model’s predictive ability across QD types, species, and exposure routes. The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo.

Item Type:Article
Subjects:Risk > Environment, health and safety aspects of nanotechnology
ID Code:11789
Deposited By:Prof Nancy Monteiro-Riviere
Deposited On:02 Mar 2012 18:06
Last Modified:02 Mar 2012 18:06

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