Nano Archive

Biodistribution of Quantum Dot Nanoparticles in Perfused Skin: Evidence of Coating Dependency and Periodicity in Arterial Extraction

Lee, Hyun A and Imran, M and Monteiro-Riviere, Nancy A and Colvin, Vicki L and Yu, William W and Riviere, Jim E (2007) Biodistribution of Quantum Dot Nanoparticles in Perfused Skin: Evidence of Coating Dependency and Periodicity in Arterial Extraction. Nano Letters .

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Abstract

Arterial extraction of quantum dots (QD) assayed by fluorescence or inductively coupled plasma (ICP) emission spectrometry were studied after infusion into isolated perfused skin. Extraction was mathematically modeled using three linear differential equations. COOH-coated QD had greater tissue deposition, assessed both by model prediction and laser confocal scanning microscopy, than did QD-PEG. Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition.

Item Type:Article
Subjects:NanoSafety > Environment, health and safety aspects of nanotechnology
ID Code:11785
Deposited By:Prof Nancy Monteiro-Riviere
Deposited On:02 Mar 2012 17:01
Last Modified:02 Mar 2012 17:01

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