Nano Archive

Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators

Ryman-Rasmussen, Jessica P and Riviere, Jim E and Monteiro-Riviere, Nancy A (2007) Variables Influencing Interactions of Untargeted Quantum Dot Nanoparticles with Skin Cells and Identification of Biochemical Modulators. Nano Letters .

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Abstract

Skin cells (NHEK) take up untargeted quantum dots (QD) with surface polyethylene glycol (PEG), amines, and carboxylic acids, but the mechanisms are unknown. Time courses of QD-NHEK interactions were determined and effects of QD surface coating, temperature, culture medium supplements and inhibitors of the cell cycle and endocytosis identified. The magnitude of QD-NHEK interactions was coating dependent. Low-temperature or unsupplemented medium decreased QD-NHEK interactions. Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions. These results are important for understanding and controlling interactions of untargeted QD with cells.

Item Type:Article
Subjects:Risk > Environment, health and safety aspects of nanotechnology
ID Code:11784
Deposited By:Prof Nancy Monteiro-Riviere
Deposited On:02 Mar 2012 16:55
Last Modified:02 Mar 2012 16:55

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