Nano Archive

Effects of Mechanical Flexion on the Penetration of Fullerene Amino Acid-Derivatized Peptide Nanoparticles through Skin

Rouse, Jillian G and Yang, Jianzhong and Ryman-Rasmussen, Jessica P and Barron, Andrew R and Monteiro-Riviere, Nancy A (2007) Effects of Mechanical Flexion on the Penetration of Fullerene Amino Acid-Derivatized Peptide Nanoparticles through Skin. Nano Letters .

Full text is not hosted in this archive but may be available via the Official URL, or by requesting a copy from the corresponding author.

Abstract

Dermatomed porcine skin was fixed to a flexing device and topically dosed with 33.5 mg/mL of an aqueous solution of a fullerene-substituted phenylalanine (Baa) derivative of a nuclear localization peptide sequence (Baa-Lys(FITC)-NLS). Skin was flexed for 60 or 90 min or left unflexed (control). Confocal microscopy depicted dermal penetration of the nanoparticles at 8 h in skin flexed for 60 and 90 min, whereas Baa-Lys-(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h. TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum.

Item Type:Article
Subjects:Risk > Environment, health and safety aspects of nanotechnology
ID Code:11782
Deposited By:Prof Nancy Monteiro-Riviere
Deposited On:02 Mar 2012 16:41
Last Modified:02 Mar 2012 16:41

Repository Staff Only: item control page