Rouse, Jillian G and Yang, Jianzhong and Ryman-Rasmussen, Jessica P and Barron, Andrew R and Monteiro-Riviere, Nancy A (2007) Effects of Mechanical Flexion on the Penetration of Fullerene Amino Acid-Derivatized Peptide Nanoparticles through Skin. Nano Letters .
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Dermatomed porcine skin was fixed to a flexing device and topically dosed with 33.5 mg/mL of an aqueous solution of a fullerene-substituted phenylalanine (Baa) derivative of a nuclear localization peptide sequence (Baa-Lys(FITC)-NLS). Skin was flexed for 60 or 90 min or left unflexed (control). Confocal microscopy depicted dermal penetration of the nanoparticles at 8 h in skin flexed for 60 and 90 min, whereas Baa-Lys-(FITC)-NLS did not penetrate into the dermis of unflexed skin until 24 h. TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum.
|Subjects:||NanoSafety > Environment, health and safety aspects of nanotechnology|
|Deposited By:||Prof Nancy Monteiro-Riviere|
|Deposited On:||02 Mar 2012 16:41|
|Last Modified:||02 Mar 2012 16:41|
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