Nano Archive

Single-coil, multisample, proton relaxation method for magnetic relaxation switch assays

Lowery, Thomas J. and Palazzolo, Robert and Wong, Susanna M. and Prado, Pablo J. and Taktak, Sonia (2008) Single-coil, multisample, proton relaxation method for magnetic relaxation switch assays. ANALYTICAL CHEMISTRY, 80 (4). pp. 1118-1123.

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Official URL: http://dx.doi.org/10.1021/ac702288r

Abstract

Nanoparticle based magnetic relaxation. switch (MRSw) biosensors offer the opportunity to develop magnetic resonance based in vitro diagnostics. Critical attributes for point of care in vitro diagnostic products include simple instrumentation and ease of use. To this end, high-resolution biexponential analysis was used to permit measurement and assignment of two samples with a single radio frequency detection coil. This approach was used to calibrate and expand the dynamic range of MRSw biosensors in a single step. The potential for easy-to-use MRSw-based diagnostics was demonstrated by combining the method for single-step measurement of two samples with a disposable, plastic cartridge and dried MRSw reagents to obtain a calibrated reading after only two steps: mix and read. Taken together, our results suggest the feasibility of developing magnetic resonance based in vitro diagnostics that offer extreme ease of use and simple instrumentation.

Item Type:Article
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Biomedical Science > Nanobiotechnology
Physical Science > Nanomagnetics
Material Science > Nanostructured materials
ID Code:1178
Deposited By:Anuj Seth
Deposited On:16 Dec 2008 16:17
Last Modified:19 Jan 2009 12:23

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