Tang, Wei and Xu, Hao and Park, Edwin J. and Philbert, Martin A. and Kopelman, Raoul (2008) Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 369 (2). pp. 579-583.
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Official URL: http://dx.doi.org/10.1016/j.bbrc.2008.02.066
The ability to prevent methylene blue (MB), a photosensitizer, from being reduced by plasma reductases will greatly improve its efficacy in photodynamic therapy (PDT) applications. We have developed a delivery approach for PDT by encapsulating MB using nanoparticle platforms (NPs). The 30-nm polyacrylamide-based NPs provide protection for the embedded MB against reduction by diaphorase enzymes. Furthermore, our data shows the matrix-protected MB efficiently induces photodynamic damage to tumor cells. The unprecedented results demonstrate the significant in vitro photodynamic effectiveness of MB when encapsulated within NPs, which promises to open new opportunities for MB in its in vivo and clinical studies. Published by Elsevier Inc.
|Uncontrolled Keywords:||methylene blue; leukomethylene blue; singlet oxygen; photodynamic therapy; polyacrylamide; nanoparticle platform; enzymatic reduction|
|Subjects:||Physical Science > Nano objects|
Material Science > Nanochemistry
Biomedical Science > Nanomedicine
|Deposited By:||Anuj Seth|
|Deposited On:||16 Dec 2008 16:24|
|Last Modified:||20 Jan 2009 10:17|
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