Nair, Pradeep R. and Alam, Muhammad A. (2007) Design considerations of silicon nanowire biosensors. IEEE TRANSACTIONS ON ELECTRON DEVICES, 54 (12). pp. 3400-3408.
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Biosensors based on silicon nanowires (Si-NWs) promise highly sensitive dynamic label-free electrical detection of biomolecules. Despite the tremendous potential and promising experimental results, the fundamental mechanism of electrical sensing of bioniolecules and the design considerations of NW sensors remain poorly understood. In this paper, we discuss the prospects and challenges of biomolecule detection using Si-NW biosensors as a function of device parameters, fluidic environment, charge polarity of biomolecules, etc., and refer to experimental results in literature to support the nonintuitive predictions wherever possible. Our results indicate that the design of Si nanobiosensor is nontrivial and as such, only careful optimization supported by numerical simulation would ensure optimal sensor performance.
|Uncontrolled Keywords:||biosensors; DNA; Poisson-Boltzmann (PB); protein detection; random dopant fluctuations; sensitivity|
|Subjects:||Analytical Science > Nanotechnology for sensing and actuating|
Physical Science > Nano objects
Biomedical Science > Nanobiotechnology
Material Science > Nanostructured materials
|Deposited By:||Anuj Seth|
|Deposited On:||17 Dec 2008 10:38|
|Last Modified:||20 Jan 2009 10:23|
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