Nano Archive

Reconstitution of aluminium and iron core in horse spleen apoferritin

Ciasca, G. and Chiarpotto, M. and Campi, G. and Bocca, B. and Rodio, M. and Pino, A. and Ricci, A. and Poccia, N. and Rossi, C. and Alimonti, A. and Amenitsch, H. and Sole, P. and Bianconi, A. (2011) Reconstitution of aluminium and iron core in horse spleen apoferritin. Journal of Nanoparticle Research, 13 (11). pp. 6149-6155.

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Abstract

This study investigates the uptake of iron and aluminium by apoferritin. In particular, we provide the first evidence that apoferritin is able to bind in vitro the physiological form of aluminium, Al(OH)4−, to reach an Al/Fe atomic ratio of about 0.15. Mass spectrometry analysis shows that the Al content increases linearly as a function of Al concentration in solution. These findings provide a better understanding of the Al uptake in vivo, confirming that the metal content of ferritin depends on the metal bio-availability.

Item Type:Article
ID Code:11544
Deposited By:Prof. Alexey Ivanov
Deposited On:05 Jan 2012 09:30
Last Modified:05 Jan 2012 09:42

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