Das, Arijit and Soehnlen, Eric and Woods, Stephan and Hegde, Ravi and Henry, Amanda and Gericke, Arne and Basu, Soumitra (2011) VEGFR-2 targeted cellular delivery of doxorubicin by gold nanoparticles for potential antiangiogenic therapy. Journal of Nanoparticle Research, 13 (12). pp. 6283-6290.
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We report a novel gold nanobioconjugate system that achieves targeted delivery of the small molecule drug doxorubicin to endothelial cells using anti-VEGFR-2 antibody conjugated gold nanoparticles (GNPs). The reported nanobioconjugate system combines the inherent ability of GNPs to undergo high levels of derivatization with the precision of antibody recognition of a cell surface antigen. Transmission electron microscopy (TEM) and surface-enhanced Raman spectroscopy (SERS) confirmed intracellular presence of the GNPs. Using a VEGFR-2 expressing cell line and a cell line that is negative for the receptor, in combination with competition assay we established the cell specific targeted delivery of the nanobioconjugate. The nanobioconjugate system described here may have potential drug delivery applications for antiangiogenic cancer therapy.
|Deposited By:||Prof. Alexey Ivanov|
|Deposited On:||05 Jan 2012 09:30|
|Last Modified:||05 Jan 2012 09:42|
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