Rezaei, Behzad and Majidi, Najmeh and Noori, Shokoofe and Hassan, Zuhair M. (2011) Multiwalled carbon nanotubes effect on the bioavailability of artemisinin and its cytotoxity to cancerous cells. Journal of Nanoparticle Research, 13 (12). pp. 6339-6346.
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Artemisinin regarded as one of the most promising anticancer drugs can bind to DNA with a binding constant of 1.04Â ÃÂ 104Â Mâ1. The electrochemical experiments indicated that for longer incubation time periods, the reduction peak current of artemisinin on carbon nanotube modified electrode increases. Therefore, the uptake of drug molecules from a solution into CNTs will be achieved automatically by adsorption of 88.7% of artemisinin onto carbon nanotubes surface without alteration in drug properties. Hence, capability of carbon nanotubes to have synergistic effect on the bioavailability of artemisinin was investigated. Experimental tests on K562 cancer cell lines growth by MTT assay proved that multi-walled carbon nanotubes can enhance the cytotoxity of artemisinin to the targeted cancer cells with unprecedented accuracy and efficiency. The IC50 values were 65 and 35Â Î¼M for artemisinin and artemisinin loaded on multi-walled carbon nanotubes, respectively; demonstrating that artemisinin loaded on multi-walled carbon nanotubes is more effective in inhibition of cancer cell lines growth.
|Deposited By:||Prof. Alexey Ivanov|
|Deposited On:||05 Jan 2012 09:30|
|Last Modified:||05 Jan 2012 09:42|
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