Nano Archive

Synthesis, characterization and drug delivery application of the temperature responsive pNIPA hydrogel

Craciunescu, I and Nan, A and Turcu, R and Kacso, I and Bratu, I and Leostean, C and Vekas, L (2009) Synthesis, characterization and drug delivery application of the temperature responsive pNIPA hydrogel. Journal of Physics: Conference Series, 182 (1). 012060.

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Official URL: http://stacks.iop.org/1742-6596/182/i=1/a=012060

Abstract

Temperature – sensitive poly (N-isopropyl acrylamide) pNIPA gels were synthesized with nano size iron oxide ferrofluids (Fe 3 O 4 ) using N, N'-methylene bis-acrylamide (BIS) as the crosslinking agent, obtaining a new type of material, named ferrogel. The swelling characteristics of these ferrogels at distinct compositions, as a function of temperature were investigated. It was found that the pNIPA ferrogels demonstrated the temperature – responsive nature, and it also showed good reversibility. The FTIR spectra of pNIPA ferrogel samples, showed the absorption region of the specific chemical groups associated with pNIPA and the Fe 3 O 4 magnetic nanoparticles. The drug release experiments were performed using atenolol (AT) in simulated gastric and intestinal media. The amount of released drug was determined by UV spectroscopy at characteristic wavelength of the drug, using a calibration curve obtained from a series of drug solution with standard concentration.

Item Type:Article
ID Code:11341
Deposited By:Prof. Alexey Ivanov
Deposited On:02 Nov 2011 00:10
Last Modified:02 Nov 2011 00:47

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