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Invitro toxicity test and searching the possibility of cancer cell line extermination by magnetic heating with using Fe 3 O 4 magnetic fluid

Linh, Pham Hoai and Thuan, Nguyen Chi and Tuan, Nguyen Anh and Thach, Pham Van and Yen, Tran Cong and Quy, Nguyen Thi and Nhung, HoangThi My and Xuyen, Phi Thi and Phuc, Nguyen Xuan and Hong, Le Van (2009) Invitro toxicity test and searching the possibility of cancer cell line extermination by magnetic heating with using Fe 3 O 4 magnetic fluid. Journal of Physics: Conference Series, 187 (1). 012008.

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Official URL: http://stacks.iop.org/1742-6596/187/i=1/a=012008

Abstract

A Fe 3 O 4 based magnetic fluid with different concentrations ranged between 0.15 ng/cell to 10 ng/cell (nano gram/cell) was used in the in vitro toxicity test on several cancer cell lines, Sarcoma 180, HeLa and H358. It shows that the fluid with a concentration of Fe 3 O 4 below 1.2 ng/cell is completely non-toxic for these cell lines. Even through in the presence of the highest concentration of 10 ng/cell, the cell viability still reaches more than 60%. The magnetic fluid with Fe 3 O 4 concentration of about 0.1 ng/cell was also used to search ex-vivo the possibility of Sarcoma 180 extermination by magnetic heating with an AC field of 120Oe and 184 KHz. The result shows that after a heat treatment for 30 min., 40% of Sarcoma 180 cells was killed.

Item Type:Article
ID Code:11331
Deposited By:Prof. Alexey Ivanov
Deposited On:02 Nov 2011 00:05
Last Modified:02 Nov 2011 00:47

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