Nano Archive

Surface modification of iron oxide nanoparticles and their conjuntion with water soluble polymers for biomedical application

Huong, Nguyen Thanh and Giang, Lam Thi Kieu and Binh, Nguyen Thanh and Minh, Le Quoc (2009) Surface modification of iron oxide nanoparticles and their conjuntion with water soluble polymers for biomedical application. Journal of Physics: Conference Series, 187 (1). 012046.

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Official URL: http://stacks.iop.org/1742-6596/187/i=1/a=012046

Abstract

Superparamagnetic iron oxide nanoparticles (SPION) coated with suitable bio-compatible substances have been used in biomedicine, particularly in magnetic resonance imaging (MRI), tissue engineering, and hyperthermia and drug delivery. In this study, we describe the synthesis of SPION and its surface modification for in-vitro experiments. The particle diameter and structure were estimated by FESEM, TEM, XRD analyses. The saturation magnetization was characterized. SPION with a mean size of 12 nm have been prepared under N 2 atmosphere, with support of natural polymeric starch, by controlling chemical coprecipitation of magnetite phase from aqueous solutions containing suitable salts ratios of Fe 2+ and Fe 3+ . The surface of SPION-nanoparticles was treated with a coordinatable agent for higher dispersion ability in water and remaining the superparamagnetic behavior. The prepared iron oxide nanoparticles were coated with starch, dextran, PEG or MPEG to extend the application potential in the quite different engineering field of nano biomedicine.

Item Type:Article
ID Code:11330
Deposited By:Prof. Alexey Ivanov
Deposited On:02 Nov 2011 00:05
Last Modified:02 Nov 2011 00:47

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