Nano Archive

Relationship between Surface Modifications of Nanoparticle and Invasion into Suspension Cells

Matsui, Y and Sakai, N and Tsuda, A and Yoneda, M (2011) Relationship between Surface Modifications of Nanoparticle and Invasion into Suspension Cells. Journal of Physics: Conference Series, 304 (1). 012051.

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Official URL: http://stacks.iop.org/1742-6596/304/i=1/a=012051

Abstract

Nanomaterials have a variety of properties for each material. There is little information available on which kinds of material properties have effects on toxicity and kinetics. This paper presents that a relationship between material properties and hazard data by undertaking a bibliographical survey at first. With respect to cytotoxicity, it probably depends mainly on the particle volume dose and to a certain degree on particle solubility. It can be concluded from these results that there is a relationship between material properties and hazard data. Many activities involving nano risk are occurring all over the world. Secondly, we assayed actually for cellular uptake of three kinds of Quantum dots (15 nm, 5.5×10 12 particles/ml) to demonstrate our result of bibliographical survey. Three different surface modification quantum dots (non-modification, -COOH, -NH3) were mixed with floating Jurkat cells in each. After thirty minute, we washed these cells three times and detected fluorescence by flow cytometer. Almost all the carboxylate particles invaded a cell, about 60% aminated them also invaded and few non-modification particles were taken up. Nanomaterials are often very broadly categorized and named based upon their basic material composition or product shape. Our results confirm that we have to examine which physical-chemical properties affect some adverse effects for each nanomaterial.

Item Type:Article
ID Code:11269
Deposited By:Prof. Alexey Ivanov
Deposited On:01 Nov 2011 23:30
Last Modified:02 Nov 2011 00:47

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