Nano Archive

Biomedical and environmental applications of magnetic nanoparticles

Tran, Dai Lam and Le, Van Hong and Pham, Hoai Linh and Hoang, Thi My Nhung and Nguyen, Thi Quy and Luong, Thien Tai and ThuHa, Phuong and Nguyen, Xuan Phuc (2010) Biomedical and environmental applications of magnetic nanoparticles. Advances in Natural Sciences: Nanoscience and Nanotechnology, 1 (4). 045013.

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This paper presents an overview of syntheses and applications of magnetic nanoparticles (MNPs) at the Institute of Materials Science, Vietnam Academy of Science and Technology. Three families of oxide MNPs, magnetite, manganite and spinel ferrite materials, were prepared in various ways: coprecipitation, sol–gel and high energy mechanical milling. Basic properties of MNPs were characterized by Vibrating Sample Magnetometer (VSM) and Physical Properties Measurement Systems (PPMS). As for biomedical application, the aim was to design a novel multifunctional, nanosized magnetofluorescent water-dispersible Fe 3 O 4 -curcumin conjugate, and its ability to label, target and treat tumor cells was described. The conjugate possesses a magnetic nano Fe 3 O 4 core, chitosan (CS) or Oleic acid (OL) as an outer shell and entrapped curcumin (Cur), serving the dual function of naturally autofluorescent dye as well as antitumor model drug. Fe 3 O 4 -Cur conjugate exhibited a high loading cellular uptake with the help of a macrophage, which was clearly visualized dually by Fluorescence Microscope and Laser Scanning Confocal Microscope (LSCM), as well as by magnetization measurement (PPMS). A preliminary magnetic resonance imaging (MRI) study also showed a clear contrast enhancement by using the conjugate. As for the environmental aspect, the use of magnetite MNPs for the removal of heavy toxic metals, such as Arsenic (As) and Lead (Pb), from contaminated water was studied.

Item Type:Article
ID Code:11176
Deposited By:Prof. Alexey Ivanov
Deposited On:01 Nov 2011 23:25
Last Modified:02 Nov 2011 00:47

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