Nano Archive

Internal distribution of micro- / nano-sized inorganic particles and their cytocompatibility

Abe, Shigeaki and Iwadera, Nobuki and Esaki, Mitsue and Kida, Ikuhiro and Mutoh, Mami and Akasaka, Tsukasa and MotohiroUo, and Yawaka, Yasutaka and Morita, Manabu and Haneda, Koichi and Yonezawa, Tetsu and Watari, Fumio (2011) Internal distribution of micro- / nano-sized inorganic particles and their cytocompatibility. IOP Conference Series: Materials Science and Engineering, 18 (19). p. 192013.

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Official URL: http://stacks.iop.org/1757-899X/18/i=19/a=192013

Abstract

Nano-sized materials have received much attention lately, both in terms of their multiple applications and their biocompatibility. From both viewpoints, understanding the biodistribution of administered nano-materials is very important. In this study, we succeeded in visualizing the biodistribution of administered nano-materials using a scanning X-ray analytical microscope and magnetic resonance imaging method. Quantitative observation was carried out by inductively coupled plasma – atomic emission spectroscopy. We observed that the administered nano-particles accumulated in the liver, lung and spleen of mice. To estimate their cytocompatibility, the nano-particles were exposed to human liver cells. The results suggested that the micro-/ nano- particles have good cytocompatibility, except for copper oxide nano-particles.

Item Type:Article
ID Code:11121
Deposited By:Prof. Alexey Ivanov
Deposited On:01 Nov 2011 23:22
Last Modified:02 Nov 2011 00:47

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