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Toxicology of engineered metal nanoparticles.

Bernardini, Giovanni and Cattaneo, Anna Giulia and Sabbioni, Enrico and Di Gioacchino , Mario and Chiriva-Internati , Maurizio and Gornati, Rosalba (2011) Toxicology of engineered metal nanoparticles. In: Handbook of Systems Toxicology. Wiley & Sons Ltd., Chicester, pp. 743-759. ISBN ISBN: 978-0-470-68401-6

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Abstract

The wide interest in nanoscience and nanotechnology leads to an ever-increasing presence of nanomaterials in the environment that in turn may be associated with potentially new and largely undefined risks for the human health and for the environment.We reviewed the experimental data on the ecotoxicology of engineered nanometals following their intentional, unavoidable or accidental dispersion in the environment, together with the benefits of their use for bioremediation. Two potential threats for the human health, the carcinogenic and allergenic risks, have been subsequently evaluated in in vitro and in vivo systems. Lung and skin inflammation and possibly mutagenesis are the mainly documented effects, but the available data remain scarce and fragmentary, and toxicity is shared by both metallic and non-metallic nanomaterials. The conclusive paragraph discusses the development of nanomedicine and the clinical use of nanometals and drugs having a metallic core. A careful evaluation of risks and benefits is mandatory even in this case.

Item Type:Book Section
Uncontrolled Keywords:allergy, cancer, ecotoxicology, magnetic nanoparticles,nanomedicine, nanotoxicology
Subjects:Social and Political Science > Societal and ethical aspects of nanotechnology
Technology > Nanotechnology and environmental applications
Biomedical Science > Nanobiotechnology
Biomedical Science > Nanotechnology for human health
NanoSafety > Environment, health and safety aspects of nanotechnology
Material Science > Nanostructured materials
Biomedical Science > Nanomedicine
Divisions:Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
ID Code:10991
Deposited By:Dr Anna Giulia Cattaneo
Deposited On:06 May 2011 12:09
Last Modified:06 May 2011 12:09

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