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Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice

Yoshida, Tokuyuki and Yoshioka, Yasuo and Fujimura, Maho and Yamashita, Kohei and Higashisaka, Kazuma and Morishita, Yuki and Kayamuro, Hiroyuki and Nabeshi, Hiromi and Nagano, Kazuya and Abe, Yasuhiro and Kamada, Haruhiko and Tsunoda, Shin-ichi and Itoh, Norio and Yoshikawa, Tomoaki and Tsutsumi, Yasuo (2011) Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice. Nanoscale Research Letters, 6 (1). pp. 1-6.


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With the increase in use of nanomaterials, there is growing concern regarding their potential health risks. However, few studies have assessed the role of the different physical characteristics of nanomaterials in allergic responses. Here, we examined whether intranasally administered silica particles of various sizes have the capacity to promote allergic immune responses in mice. We used nanosilica particles with diameters of 30 or 70 nm (nSP30 or nSP70, respectively), and conventional micro-sized silica particles with diameters of 300 or 1000 nm (nSP300 or mSP1000, respectively). Mice were intranasally exposed to ovalbumin (OVA) plus each silica particle, and the levels of OVA-specific antibodies (Abs) in the plasma were determined. Intranasal exposure to OVA plus smaller nanosilica particles tended to induce a higher level of OVA-specific immunoglobulin (Ig) E, IgG and IgG1 Abs than did exposure to OVA plus larger silica particles. Splenocytes from mice exposed to OVA plus nSP30 secreted higher levels of Th2-type cytokines than mice exposed to OVA alone. Taken together, these results indicate that nanosilica particles can induce allergen-specific Th2-type allergic immune responses in vivo. This study provides the foundations for the establishment of safe and effective forms of nanosilica particles.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Physics
Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:10957
Deposited By:JNCASR
Deposited On:16 Jul 2011 07:37
Last Modified:16 Jul 2011 07:37

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