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Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies

Sanna, Vanna and Roggio, Anna Maria and Posadino, Anna Maria and Cossu, Annalisa and Marceddu, Salvatore and Mariani, Alberto and Alzari, Valeria and Uzzau, Sergio and Pintus, Gianfranco and Sechi, Mario (2011) Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies. Nanoscale Research Letters, 6 (1). pp. 1-9.

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Official URL: http://www.nanoscalereslett.com/content/6/1/260

Abstract

Docetaxel (Dtx) chemotherapy is the optional treatment in patients with hormone-refractory metastatic prostate cancer, and Dtx-loaded polymeric nanoparticles (NPs) have the potential to induce durable clinical responses. However, alternative formulations are needed to overcome the serious side effects, also due to the adjuvant used, and to improve the clinical efficacy of the drug.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanostructured materials
Material Science > Nanochemistry
Divisions:Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:10919
Deposited By:JNCASR
Deposited On:18 Oct 2011 08:20
Last Modified:18 Oct 2011 08:20

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