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Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface

Mori, Taizo and Okamoto, Ken and Endo, Hiroshi and Sakakibara, Keita and Hill, Jonathan P and Shinoda, Satoshi and Matsukura, Miki and Tsukube, Hiroshi and Suzuki, Yasumasa and Kanekiyo, Yasumasa and Ariga, Katsuhiko (2011) Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface. Nanoscale Research Letters, 6 (1). pp. 1-6.

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Official URL: http://www.nanoscalereslett.com/content/6/1/304

Abstract

Molecular machines embedded in a Langmuir monolayer at the air-water interface can be operated by application of lateral pressure. As part of the challenge associated with versatile sensing of biologically important substances, we here demonstrate discrimination of nucleotides by applying a cholesterol-armed-triazacyclononane host molecule. This molecular machine can discriminate ribonucleotides based on a twofold to tenfold difference in binding constants under optimized conditions including accompanying ions in the subphase and lateral surface pressures of its Langmuir monolayer. The concept of mechanical tuning of the host structure for optimization of molecular recognition should become a novel methodology in bio-related nanotechnology as an alternative to traditional strategies based on increasingly complex and inconvenient molecular design strategies.

Item Type:Article
Subjects:Physical Science > Nanophysics
Physical Science > Nano objects
Material Science > Nanochemistry
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Physics
Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:10887
Deposited By:JNCASR
Deposited On:18 Oct 2011 08:58
Last Modified:18 Oct 2011 08:58

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