Wu, Zhuo-Jie and Luo, Zhiquan and Rastogia, Ashish and Stavchansky, Salomon and Bowman, Phillip D. and Ho, Paul S. (2011) Micro-fabricated perforated polymer devices for long-term drug delivery. BIOMEDICAL MICRODEVICES, 13 (3). pp. 485-491. ISSN 1387-2176 (Print) 1572-8781 (Online)
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Fabrication techniques have been developed to produce a perforated polymer microtube as a drug delivery device. The technique consists of first forming a silicon platform with trenches and alignment marks to hold the tubes for subsequent processing. Photolithography and reactive ion etching with an inductively coupled plasma source were used to fabricate micro holes on the surface of polyimide tubes. Several materials have been used to form the etching mask, including titanium film deposited by e-beam evaporation and SiO2 and SiNx films deposited by high-density plasma chemical vapor deposition (HDPCVD). Three equidistant holes of 20Â Î¼m in diameter were fabricated on polyimide tubes (I.D. = 125Â Î¼m). The perforated tubes were loaded with ethinyl estradiol and tested for drug release in phosphate buffered saline (pHâ=â7.1) at 37Â°C. Zero order release was observed over a period of 30Â days with a potential to be extended to 4Â years.
|Uncontrolled Keywords:||Drug delivery device – Microfabrication – Polymer tube – Polyimide|
|Subjects:||Biomedical Science > Nanobiotechnology|
Biomedical Science > Nanomedicine
|Deposited On:||08 Jun 2011 11:05|
|Last Modified:||08 Jun 2011 11:05|
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