Nano Archive

Processing of polymer nanofibers through electrospinning as drug delivery systems

Kenawy, El-Refaie and Abdel-Hay, Fouad and El-Newehy, Mohamed H. and Wnek, Gary E. (2009) Processing of polymer nanofibers through electrospinning as drug delivery systems. Materials Chemistry and Physics, 113 (1). pp. 296-302. ISSN 0254-0584

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Abstract

The use of electrospun fibers as drug carriers could be promising in the future for biomedical applications, especially postoperative local chemotherapy. In this research work, electrospun fibers were developed as a new system for the delivery of ketoprofen as non-steroidal anti-inflammatory drug (NSAID). The fibers were made either from polycaprolactone (PCL) as a biodegradable polymer or polyurethane (PU) as a non-biodegradable polymer, or from the blends of the two. The release of the ketoprofen was followed by UV–vis spectroscopy in phosphate buffer of pH 7.4 at 37 and 20 °C. The results showed that the release rates from the polycaprolactone, polyurethane and their blend are similar. However, the blend of the polycaprolactone with polyurethane improved its visual mechanical properties. Release profiles from the electrospun mats were compared to cast films of the various formulations. Keywords: Electrospinning; Polycaprolactone; Polyurethane; Drug delivery; Ketoprofen

Item Type:Article
Subjects:Material Science > Nanofabrication processes and tools
Biomedical Science > Nanotechnology for human health
Material Science > Bio materials
Material Science > Nanostructured materials
Divisions:Faculty of Engineering, Science and Mathematics > School of Chemistry
ID Code:10582
Deposited By:Asst. Prof. Mohamed El-Newehy
Deposited On:01 Feb 2011 19:00
Last Modified:01 Feb 2011 19:00

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