Tran-Minh, Nhut and Dong, Tao and Su, Qianhua and Yang, Zhaochu and Jakobsen, Henrik and Karlsen, Frank (2010) Design and optimization of non-clogging counter-flow microconcentrator for enriching epidermoid cervical carcinoma cells. Biomedical Microdevices, 13 (1). pp. 179-190.
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Clogging failure is common for microfilters in living cells concentration; for instance, the CaSki Cell-lines (Epidermoid cervical carcinoma cells) utilizing the flat membrane structure. In order to avoid the clogging, counter-flow concentration units with turbine blade-like micropillar are proposed in microconcentrator design. Due to the unusual geometrical-profiles and extraordinary microfluidic performance, the cells blocking does not occur even at permeate entrances. A counter-flow microconcentrator was designed, with both processing layer and collecting layer arranged in terms of the fractal based honeycomb structure. The device was optimized by coupling Artificial Neuron Network (ANN) and Computational Fluid Dynamics (CFD). The excellent concentration ratio of a final microconcentrator was presented in numerical results.
|Subjects:||Biomedical Science > Nanoscale biological processes|
|Deposited On:||06 Jun 2011 08:42|
|Last Modified:||06 Jun 2011 08:42|
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