Elizarov, Arkadij M. and Meinhart, Carl and Miraghaie, Reza and Dam, R. Michael and Huang, Jiang and Daridon, Antoine and Heath, James R. and Kolb, Hartmuth C. (2010) Flow optimization study of a batch microfluidics PET tracer synthesizing device. Biomedical Microdevices, 13 (1). pp. 231-242.
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We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.
|Subjects:||Biomedical Science > Nanoscale biological processes|
|Deposited On:||06 Jun 2011 08:51|
|Last Modified:||06 Jun 2011 08:51|
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