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ObservatoryNano Briefing No 5. Health. Next Generation Sequencing.

Moore, Richard and Gloekler, Jorn (2010) ObservatoryNano Briefing No 5. Health. Next Generation Sequencing. Other. ObservatoryNano.

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Official URL: http://www.observatorynano.eu/project/catalogue/B/

Abstract

DNA sequencing technologies over the last three decades have been based on principles first developed by Frederick Sanger in the mid-1970s. Subsequent improvements have led to an increase in the length of the DNA fragments able to be read and a move away from radioactive labelling towards detection using fluorescent markers. Next generation sequencing (NGS) has taken some of the later developments of the Sanger method and has added another dimension in the form of high-throughput technologies that can parallelize the process, that integrate reactions at the micro- or nanoscale on chip surfaces, and that produce thousands or millions of sequences at once. These high-throughput sequencing technologies are intended to lower the costs of DNA sequencing far beyond that possible with earlier methods.

Item Type:Monograph (Other)
Subjects:Biomedical Science > Nanobiotechnology
Biomedical Science > Nanomedicine
ID Code:10471
Deposited By:M T V
Deposited On:06 Jan 2011 13:56
Last Modified:06 Jan 2011 13:56

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