Nano Archive

Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents

Jeong, Sang Young and Kim, Hyo Jeong and Kwak, Byung-Kook and Lee, Ha-Young and Seong, Hasoo and Shin, Byung Cheol and Yuk, Soon Hong and Hwang, Sung-Joo and Cho, Sun Hang (2010) Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents. Nanoscale Research Letters, 5 (12). pp. 1970-1976.

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Official URL: http://www.nanoscalereslett.com/content/pdf/1556-2...

Abstract

Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C16-ED-DOTA-Gd.

Item Type:Article
Subjects:Biomedical Science > Nanotechnology for human health
Biomedical Science > Nanomedicine
Divisions:Faculty of Medicine, Health and Life Sciences > School of Biological Sciences
Faculty of Medicine, Health and Life Sciences > School of Medicine
ID Code:10413
Deposited By:JNCASR
Deposited On:18 Oct 2011 08:20
Last Modified:18 Oct 2011 08:20

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