Jeong, Sang Young and Kim, Hyo Jeong and Kwak, Byung-Kook and Lee, Ha-Young and Seong, Hasoo and Shin, Byung Cheol and Yuk, Soon Hong and Hwang, Sung-Joo and Cho, Sun Hang (2010) Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents. Nanoscale Research Letters, 5 (12). pp. 1970-1976.
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Official URL: http://www.nanoscalereslett.com/content/pdf/1556-2...
Abstract
Biocompatible poly-[N-(2-hydroxyethyl)-d,l-aspartamide]-methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C16) conjugated with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (1H NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C16-ED-DOTA-Gd.
| Item Type: | Article |
|---|---|
| Subjects: | Biomedical Science > Nanotechnology for human health Biomedical Science > Nanomedicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Biological Sciences Faculty of Medicine, Health and Life Sciences > School of Medicine |
| ID Code: | 10413 |
| Deposited By: | JNCASR |
| Deposited On: | 18 Oct 2011 08:20 |
| Last Modified: | 18 Oct 2011 08:20 |
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