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Electrochemical, AFM and QCM studies on ferritin immobilized onto a self-assembled monolayer-modified gold electrode

Tominaga, M and Ohira, Akihiro and Yamaguchi, Yoshihisa and Kunitake, Masashi (2004) Electrochemical, AFM and QCM studies on ferritin immobilized onto a self-assembled monolayer-modified gold electrode. Journal of Electroanalytical Chemistry, 566 (2). pp. 323-329. ISSN 00220728

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A ferritin-immobilized electrode based on self-assembled monolayer (SAM)-modified gold electrodes was developed. Various alkane thiols containing functional groups as the terminal group were used for the SAMs. The ferritin-immobilized SAM-modified electrodes were characterized by electrochemical, atomic force microscopy (AFM) and quartz crystal microbalance (QCM) techniques. The results indicated that ferritin was selectively immobilized onto amino terminal alkane thiol-modified electrodes by the electrostatic interaction between ferritin and the terminal functional groups of the SAMs. The ferritin-immobilized modified electrode showed a direct electron transfer reaction between ferritin and the electrode. The electrochemically regulated uptake and release of iron ions for ferritin immobilized on the SAMs was demonstrated. The AFM and QCM results showed that ferritin molecules covered the whole electrode surface at almost a full monolayer level. The results obtained in this work indicate that ferritin has potential for a biomaterial in nanomaterial synthesis for potential magnetic, catalytic and biomedical sensing applications.

Item Type:Article
Additional Information:Article Outline 1. Introduction 2. Experimental 2.1. Materials 2.2. Instrumentation 2.3. Preparation of the electrode 2.4. Preparation of modified electrode 3. Results and discussion 3.1. Immobilization and electrochemistry of ferritin 3.2. Surface coverage of ferritin 3.3. Chain length dependence of amino terminal alkane thiol 4. Summary Acknowledgements References
Uncontrolled Keywords:Ferritin; Modified electrode; AFM; Monolayer; Redox reaction
Subjects:Analytical Science > Nanotechnology for sensing and actuating
Material Science > Bio materials
ID Code:104
Deposited By:Lesley Tobin
Deposited On:08 Jan 2009 13:08
Last Modified:08 Jan 2009 13:08

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